Science
Science is the practice of finding good Explanations. Science is a way of dealing with theories regardless of whether or not one believes them. They are judged according to whether or not they’re good explanations. And if a particular explanation ends up being the only explanation that survives the intense criticism that reason and science can apply, then it’s not so much adopted at that point as just not discarded. It has survived for the moment.
Universal Computation
Anything that can be written down as a program can be computed given the right memory and enough time. Explanations are a form of information, and information can only be processed in basically one way—with computation of the kind invented by Babbage and Turing.